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Reversible cutaneous lymphoma occurring during methotrexate therapy

Identifieur interne : 002A23 ( Main/Exploration ); précédent : 002A22; suivant : 002A24

Reversible cutaneous lymphoma occurring during methotrexate therapy

Auteurs : R. Viraben [France] ; P. Brousse [France] ; L. Lamant [France]

Source :

RBID : ISTEX:BEE4962ABED858B5E2F9093D925804377F78D4E9

Abstract

Summary A B‐cell lymphoma, restricted to the skin, developed in a 58‐year‐old man receiving methotrexate for non‐rheumatoid peripheral arthritis, with the simultaneous occurrence of a cytolytic hepatitis and carcinoma of the lung. Two weeks after methotrexate was stopped, both the skin tumour and the hepatitis disappeared spontaneously, with no recurrence during a 12‐month follow‐up period. Immunoglobulin gene rearrangement was shown by polymerase chain reaction (PCR) but in situ hybridization failed to reveal neoplastic cells positive for Epstein‐Barr virus (EBV).

Url:
DOI: 10.1046/j.1365-2133.1996.d01-946.x


Affiliations:


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